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. 2020 Sep 10;46(5):1653–1660. doi: 10.3892/ijmm.2020.4723

Figure 6.

Figure 6

FOSL2 was identified as a direct target of miRNA-597-3p. (A) Specific binding sequences of FOSL2 3'-UTR and miRNA-597-3p were predicted using TargetScan 7.0. (B) Dual-luciferase reporter assay results demonstrated the relative luciferase activity in each group. **P<0.01 vs. FOSL2 wt + miRNA-597-3p NC; #P<0.01 vs. FOSL2 mut + miRNA-597-3p NC. (C) Reverse transcription-quantitative PCR results demonstrated that FOSL2 mRNA was significantly upregulated in CSCC tissues. **P<0.01 vs. corresponding adjacent tissues. (D) FOSL2 mRNA were significantly decreased in a miRNA-597-3p mimic group, and substantially increased in miRNA-597-3p inhibitor group. **P<0.01 vs. miRNA-597-3p NC group. miRNA, microRNA; CSCC, cutaneous squamous cell carcinoma; NC, negative control; wt, wild type; mut, mutated type; UTR, untranslated region; FOSL2, Fos-related antigen 2.