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. 2020 Sep 9;46(5):1743–1754. doi: 10.3892/ijmm.2020.4722

Figure 1.

Figure 1

MKLN1-AS is highly expressed in HCC and is associated with poor prognosis. (A) MKLN1-AS expression in HCC samples and healthy samples from TCGA and GTEx databases. TCGA and GTEx databases were used to analyze the (B) overall survival and (C) disease-free survival rates in patients with HCC exhibiting high or low MKLN1-AS expression. (D) Relative expression of MKLN1-AS in 65 pairs of HCC tissues and corresponding adjacent healthy tissues was assessed using RT-qPCR. **P<0.01 compared with adjacent healthy tissues. (E) RT-qPCR was used to measure MKLN1-AS expression in four HCC cell lines (SNU-182, HuH7, Hep3B and SNU-398) and THLE-3 cells. **P<0.01 compared with THLE-3. Kaplan-Meier analysis was used to assess the association between MKLN1-AS expression and (F) overall survival or (G) disease-free survival in the 65 patients with HCC. MKLN1-AS, muskelin 1 antisense RNA; HCC, hepatocellular carcinoma; TCGA, The Cancer Genome Atlas; RT-qPCR, reverse transcription-quantitative PCR; GTEx, Genotype Tissue Expression.