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. Author manuscript; available in PMC: 2021 Sep 25.
Published in final edited form as: Circ Res. 2020 Sep 24;127(8):1109–1111. doi: 10.1161/CIRCRESAHA.120.317910

Figure 1. Breaking the link between mitochondrial protein acetylation and pressure-overload induced adverse remodeling.

Figure 1.

The differences in the effect of the DKO to the whole body Sirt3 KO mice are shown within the heart subjected to pressure overload. The dissociation of the extent to mitochondrial protein acetylation in the DKO mice with both adverse effects on mitochondrial function and cardiac adaptation to TAC are depicted with the broken chain link. The text box on the right suggests approaches to be pursued to answer outstanding questions. Abbreviations: CrAT - carnitine acetyl transferase; DKO - double Sirt3 and CrAT KO mice; GCN5L1 - General control of amino acid synthesis 5 like 1 and TAC – transverse aortic constriction.