TABLE 3.
Risk factors for disease-free survival in all cases
| n | 5-Year (%) | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
| HR (95 % CI) | P value | HR (95 % CI) | P value | |||
| Age (years) | <0.001 | |||||
| <50 | 391 | 89.7 | 1 | 1 | ||
| 50–59 | 482 | 79.5 | 2.09 (1.36–3.22) | 1.96 (1.26–3.04) | 0.003 | |
| ≥60 | 466 | 72.3 | 3.19 (2.09–4.86) | 2.67 (1.70–4.21) | <0.001 | |
| Ethnicity | 0.003 | |||||
| Caucasian | 190 | 70.0 | 1 | 1 | ||
| African American | 41 | 60.7 | 1.69 (0.85–3.38) | 0.53 (0.26–1.10) | 0.09 | |
| Hispanic | 568 | 83.5 | 0.61 (0.40–0.93) | 0.76 (0.49–1.18) | 0.22 | |
| Asian | 539 | 81.2 | 0.76 (0.50–1.17) | 0.80 (0.52–1.23) | 0.31 | |
| Histology | <0.001 | |||||
| Endometrioid | 1098 | 86.3 | 1 | 1 | ||
| Serous | 84 | 41.6 | 5.79 (3.95–8.48) | 1.02 (0.63–1.67) | 0.92 | |
| Clear cell | 31 | 47.1 | 6.34 (3.55–11.3) | 1.34 (0.71–2.55) | 0.37 | |
| Other | 126 | 62.5 | 3.14 (2.14–4.60) | 1.28 (0.94–1.97) | 0.25 | |
| Grade | <0.001 | |||||
| Low grade | 1033 | 88.0 | 1 | 1 | ||
| High grade | 302 | 54.8 | 5.33 (3.99–7.12) | 1.89 (1.31–2.73) | 0.001 | |
| Stage | <0.001 | |||||
| I | 951 | 91.3 | 1 | 1 | ||
| II | 101 | 79.8 | 2.67 (1.52–4.68) | 2.87 (1.62–5.08) | <0.001 | |
| III | 192 | 60.1 | 5.59 (3.84–8.14) | 4.73 (3.18–7.02) | <0.001 | |
| IV | 90 | 22.2 | 22.1 (15.2–32.0) | 15.8 (10.2–24.5) | <0.001 | |
| EC-AIA | 0.014 | |||||
| No | 1294 | 80.6 | 1 | 1 | ||
| Yes | 46 | 71.4 | 2.18 (1.15–4.13) | 3.07 (1.55–6.08) | 0.001 | |
The log-rank test was performed for univariate analysis and Cox the proportional hazard regression test for multivariate analysis. Significant P values are in bold type. Chi square value: 551.6 (P < 0.001)
HR Hazard ratio, CI confidence interval, EC-AIA endometrial cancer arising in adenomyosis