TABLE 4.
Risk factors for disease-free survival in stage I
| n | 5-Year (%) | Univariate | Multivariate | |||
|---|---|---|---|---|---|---|
| HR (95 % CI) | P value | HR (95 % CI) | P value | |||
| Age (years) | 0.001 | |||||
| <50 | 280 | 96.2 | 1 | 1 | ||
| 50–59 | 337 | 92.1 | 2.05 (0.85–4.94) | 1.98 (0.81–4.82) | 0.13 | |
| ≥60 | 334 | 85.6 | 3.97 (1.73–9.09) | 2.34 (0.97–5.63) | 0.057 | |
| Ethnicity | 0.019 | |||||
| Caucasian | 135 | 83.6 | 1 | 1 | ||
| African American | 24 | 100 | NA | NA | 0.97 | |
| Hispanic | 423 | 93.8 | 0.35 (0.16–0.75) | 0.49 (0.22–1.14) | 0.098 | |
| Asian | 369 | 90.6 | 0.72 (0.35–1.46) | 0.71 (0.33–1.54) | 0.39 | |
| Histology | <0.001 | |||||
| Endometrioid | 837 | 93.6 | 1 | 1 | ||
| Serous | 36 | 64.2 | 4.39 (1.84–10.5) | 0.73 (0.24–2.19) | 0.58 | |
| Clear cell | 14 | 62.2 | 9.14 (3.23–25.8) | 1.99 (0.60–6.59) | 0.26 | |
| Other | 64 | 80.0 | 3.70 (1.77–7.73) | 1.82 (0.79–4.16) | 0.16 | |
| Grade | <0.001 | |||||
| Low grade | 815 | 94.4 | 1 | 1 | ||
| High grade | 134 | 72.3 | 6.00 (3.48–10.3) | 4.19 (2.08–8.46) | <0.001 | |
| EC-AIA | <0.001 | |||||
| No | 921 | 92.0 | 1 | 1 | ||
| Yes | 30 | 68.9 | 5.21 (2.22–12.2) | 3.90 (1.46–10.4) | 0.007 | |
The log-rank test for univariate analysis and the Cox proportional hazard regression test for multivariate analysis. Significant P values are in bold type. Chi square value: 87.5 (P < 0.001)
HR Hazard ratio, CI confidence interval, NA not available, EC-AIA endometrial cancer arising in adenomyosis