Table 1.
Platinum non-compartmental plasma and tissue pharmacokinetic parameters after IV administration to female Swiss Webster of 60 mg/kg carboplatin, or the combination with 300 mg/kg iohexol.
| Carboplatin (mg/kg) | 60 | 60 |
| Iohexol (mg/kg) | - | 300 |
| Parameter | ||
| Exact dose (mg/kg) | 59.97 | 56.86 |
| Plasma (ultrafilterable) | ||
| Cmax (μg/mL) | 77.7 (7.5) | 75.5 (5.9) |
| Half-life (min) | 31.3 | 30.9 |
| AUC0-t (μg/mL•min) | 1878 | 1749 |
| AUC0-inf (μg/mL•min) | 1920 | 1791 |
| Vss (mL/kg) | 346 | 368 |
| CL (mL/min/kg)* | 16.4 | 16.7 |
| Plasma (total) | ||
| Cmax (μg/mL) | 81.5 (2.9) | 79.2 (7.4) |
| Half-life (min) | 97.5 | 102 |
| AUC0-t (μg/mL•min) | 2116 | 1794 |
| AUC0-inf (μg/mL•min) | 2179 | 1820 |
| Vss (mL/kg) | 642 | 554 |
| CL (mL/min/kg) | 14.5 | 16.4 |
| Kidney | ||
| Cmax (μg/g) | 120 (12) | 226 (25) |
| Tmax (min) | 5 | 5 |
| Half-life (min) | 558 | 174 |
| AUC0-t (μg/g•min) | 5421 | 7,277 |
| AUC0-inf (μg/g•min) | 9,,757 | 8,367 |
| Bone marrow | ||
| Cmax (ng/mg prot) | 60.8 (10.1) | 43.5 (4.9) |
| Tmax (min) | 5 | 15 |
| Half-life (min) | 134 | 243 |
| AUC0-t (ng/mg•min) | 9,134 | 6,537 |
| AUC0-inf (ng/mg•min) | 12,692 | 12,687 |
AUC0-t, area under the plasma concentration versus time curve till the last observed time point; AUC0-inf, AUC extrapolated to infinity; CL, total body clearance; Cmax, maximum plasma concentration (mean with standard deviation); Tmax, time of Cmax; Vss, volume of distribution at steady-state.
*
P=0.94