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. 2020 Aug 20;295(39):13410–13418. doi: 10.1074/jbc.AC120.014993

Figure 3.

Figure 3.

Defining the consequences of FH rescue in HLRCC at the whole-proteome level via quantitative ReDiMe labeling. a, workflow for whole-proteome ReDiMe analysis of UOK268 HLRCC cells. b, gene ontology terms encompassing proteins found to be down-regulated upon FH rescue in kidney-derived HLRCC cells. c, gene ontology terms encompassing proteins found to be up-regulated upon FH rescue in kidney-derived HLRCC cells. d, influence of FH rescue on TCA cycle enzyme expression. Genes boxed in green are down-regulated >2-fold in the FH rescue (FH+/+) UOK268 cell line relative to mutant (FH−/−). e, influence of FH rescue on NAD(P)H-producing mitochondrial metabolic enzymes. Genes boxed in green are down-regulated >2-fold in the FH rescue UOK268 cell line relative to mutant.