Figure 1.
Physicochemical properties of fragment libraries screened. A, composition of fragment libraries. B, scatter plot of AlogP versus molecular weight (MW) for all fragments screened against PrP using 19F or STD NMR. C and D, number of hydrogen bond donors (HBD) or hydrogen bond acceptors (HBA). Orange denotes compliance with the “Rule of Three” (62), and black denotes noncompliance.