Table 1.

Summary of NMR fragment screening^a

Library name	Compounds screened	Pools with hits	Retested by STD	Retested by TROSY	Validated hits
Broad Institute 19F library	785	14	14	5	0
Broad Institute 1st gen STD library	1,116	16	15	4	0
Broad Institute 2nd gen STD library	1,823	43	55	34	1
Schreiber chiral collection	381	1	5	0	0
ChemBridge high-solubility subset	2,525	31	149	37	0
Total	6,630	105	238	80	1

^a “Compounds screened” lists the total number of compounds in a given collection of molecules. “Pools with hits” indicates the number compound pools with observed hits. “Retested by STD” indicates the number of individual compounds that were retested for STD signal from each hit pool. “Retested by TROSY” shows the number of compounds that were advanced to 2D TROSY NMR.