Table 2.

Analogs of compound 1 tested by STD and TROSY NMR^a

Compound						STD	TROSY
	R1	R2	R3	R4	X
1	Cl	Cl	Me	H	N	+	+
2	Me	Me	Me	H	N	+	−
3	F	F	Me	H	N	−	±
4	H	CN	Me	H	N	−	−
5	Cl	Cl	OH	H	N	−	±
6	Cl	Cl	H	H	N	+	+
7	Cl	H	Me	H	N	−	−
8	Cl	Cl	Et	H	N	+	+
9	Cl	Cl	Me	Et	N+-Et	−	±
10	Cl	Cl	Me	Me	N	+	+
11	Br	Cl	H	H	N	+	±
12	Br	Br	H	H	N	+	±
13	Cl	Cl	CH2OH	H	CH	+	±
14	Cl	Cl	H	H	CH	+	±
15	Cl	Br	H	H	CH	+	±
16	Cl	OMe	H	H	CH	±
17	OMe	Cl	H	H	CH	−
18	Cl	F	H	H	CH	−
19	F	Cl	H	H	CH	±
20	Br	Cl	H	H	CH	+	±

^a Analogs of 1 were initially tested by STD NMR, and positive STD hits were assayed by TROSY. + indicates positive STD or TROSY signal; − indicates no STD or TROSY signal; ± indicates borderline positive signal. Blank cells indicate that the analog was not tested. All spectra were assessed by visual inspection.