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. Author manuscript; available in PMC: 2020 Sep 28.
Published in final edited form as: Cell Rep. 2020 Aug 4;32(5):107995. doi: 10.1016/j.celrep.2020.107995

Figure 6. Modeling of Caspase-2-PIDDosome Activity Captures the Switch in p53 Dynamics after Mitosis.

Figure 6.

(A) Depiction of the minimal model used to computationally test for switching behavior following mitosis; equations governing this model are described in the text. The model is based on Heltberg et al. (2019), with the addition of PIDDosome-dependent degradation of Mdm2 following mitosis.

(B) Simulated p53 levels over time when running this computational model with the parameters in Table S1. A post-mitotic rise in p53 levels is observed when PIDDosome-dependent MDM2 degradation occurs after mitosis.