Table 2. PrediXcan significant genes significant (lfsr < 0.05) gene-tissue pairs from PrediXcan analysis.

lfsr represents the local false sign rate as calculated using adaptive shrinkage [32]. P(PRACTICAL) represents P-value for the gene-tissue pair in the S-PrediXcan analysis of the PRACTICAL summary statistics. Beta(PRACTICAL) represents the effect direction and size predicted from S-PrediXcan. “NA” means that the gene was not tested in the PRACTICAL summary statistics.

Population	Gene	Tissue	lfsr	P	Beta	P (PRACTICAL)	Beta (PRACTICAL)
African American	EBPL	Brain_Cerebellar_Hemisphere	0.0423	5.25E-05	-0.022	0.3	0.006
African American	EBPL	Brain_Spinal_cord_cervical_c-1	0.0485	4.94E-05	-0.032	0.551	0.005
Japanese American	PLCL1	Adrenal_Gland	0.0448	9.72E-07	0.752	0.419	-0.068
Japanese American	PLCL1	Artery_Aorta	0.0435	9.72E-07	0.738	0.419	-0.067
Japanese American	NKX3-1	Brain_Caudate_basal_ganglia	0.0472	1.05E-05	-0.208	3.61E-25	-0.288
Japanese American	FAM227A	Brain_Nucleus_accumbens_basal_ganglia	0.042	9.13E-06	-0.211	NA	NA
Japanese American	NKX3-1	Brain_Putamen_basal_ganglia	0.0475	1.05E-05	-0.212	1.70E-46	-0.215
Japanese American	FAM227A	Brain_Putamen_basal_ganglia	0.0379	8.21E-06	-0.183	NA	NA
Japanese American	NKX3-1	Brain_Substantia_nigra	0.0209	3.80E-06	-0.238	1.18E-20	-0.288
Japanese American	FAM227A	Esophagus_Mucosa	0.0444	9.80E-06	-0.206	NA	NA
Japanese American	NKX3-1	Heart_Left_Ventricle	0.0469	1.05E-05	-0.202	3.61E-25	-0.28
Japanese American	FAM227A	Heart_Left_Ventricle	0.0434	9.22E-06	-0.222	NA	NA
Japanese American	NKX3-1	Liver	0.0468	1.05E-05	-0.198	3.61E-25	-0.274
Japanese American	PLCL1	Lung	0.0485	9.72E-07	0.797	0.419	-0.072
Japanese American	NKX3-1	Muscle_Skeletal	0.0413	8.02E-06	-0.147	3.61E-25	-0.375
Japanese American	PLCL1	Nerve_Tibial	0.031	1.40E-06	0.44	0.537	-0.033
Japanese American	FAM227A	Pituitary	0.0418	9.09E-06	-0.178	NA	NA
Japanese American	FAM227A	Prostate	0.045	1.00E-05	-0.186	NA	NA
Japanese American	COQ10B	Thyroid	0.0418	2.29E-07	-1.138	0.298	0.13