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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Chem Soc Rev. 2020 Sep 1;49(17):6402–6442. doi: 10.1039/d0cs00705f

Table 3.

Summary of microfluidic intestinal models.

Organ geometry Cell source Targeted application Refs
2D membrane Caco-2 -Modeling gut structure and function
-Microbial interactions with the gut epithelium
-Modeling intestinal inflammatory diseases
-Evaluation of anti-inflammatory probiotics and antibiotics
103, 104, 109, 112, 115117, 123
Cell-lined channel Caco-2 -Drug-induced barrier dysfunction 111, 126
Lumen (circulara) Caco-2 and myofibroblasts -Modelling gut structure and function
-Microbial interactions with the gut epithelium
122
Villi-shaped scaffold Caco-2 -Modelling gut structure and function 106, 107, 110
a

Lumen with a circular cross-section

Caco-2 – Colorectal adenocarcinoma cell line