Table 3.
Summary of microfluidic intestinal models.
| Organ geometry | Cell source | Targeted application | Refs |
|---|---|---|---|
| 2D membrane | Caco-2 | -Modeling gut structure and function -Microbial interactions with the gut epithelium -Modeling intestinal inflammatory diseases -Evaluation of anti-inflammatory probiotics and antibiotics |
103, 104, 109, 112, 115–117, 123 |
| Cell-lined channel | Caco-2 | -Drug-induced barrier dysfunction | 111, 126 |
| Lumen (circulara) | Caco-2 and myofibroblasts | -Modelling gut structure and function -Microbial interactions with the gut epithelium |
122 |
| Villi-shaped scaffold | Caco-2 | -Modelling gut structure and function | 106, 107, 110 |
a
Lumen with a circular cross-section
Caco-2 – Colorectal adenocarcinoma cell line