FIGURE 5.

Effect of transplantation on spermatogenic endpoints. Ratio of the values for the transplanted side to the sham-transplanted side for (A, D) testis weights, (B, E) epididymal sperm numbers, and (C, F) tubule differentiation indices (TDI) at the time of harvest, in groups of irradiated monkeys without GnRH-ant treatment or with two different GnRH-ant treatments. Panels A-C show calculations based on all 15 monkeys; values in D-F were calculated on 13 monkeys after excluding the two monkeys that had appreciable donor-derived spermatozoa (#164 from no GnRH-ant and #076 from pre–GnRH-ant group) in order to show effects of transplantation on endogenous spermatogenesis. The relative epididymal sperm counts and TDI are plotted using the log-transformed data. A-C: n = 5 in all groups except in B, n = 4 for sperm count of the pre + post–GnRH-ant group; D-F: n = 4 for the no GnRH-ant and pre–GnRH-ant groups and for the pre + post–GnRH-ant group in E; n = 5 for the pre + post–GnRH-ant group in D and F. In all cases, statistics were computed in one-sample tests comparing the ratios to “1.” *P < .05, Wilcoxon test; †P = .068, Wilcoxon test; ‡P < .05, t test