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. 2020 Sep 28;223:121704. doi: 10.1016/j.talanta.2020.121704

Fig. 3.

Fig. 3

(A)RT-LAMP combined with NPs-based biosensor for diagnosis of COVID-19. a: The principle of NBS for visualization of COVID-19 RT-LAMP products. b: NBS applied for reporting the results. c: VDR applied for reporting the results. NBS (b) Signals (c) 1–8 represented the plasmid levels of 1.2 × 104, 1.2 × 103, 1.2 × 102, 1.2 × 101, 1.2 × 10°, 1.2 × 10−1, 1.2 × 10−2 copies per reaction and blank control. The plasmid levels of 1.2 × 104 to 1.2 × 101 copies per reaction produced the positive reactions [75]. (B) Rapid and sensitive detection of anti-COVID-19 IgG using lanthanide-doped NPs-based lateral flow immunoassay. a: Schematic illustration of the developed assay. b: Test results for 58 serum samples, including 51 normal and 7 positive samples. *P < 0.05, ****P < 0.0001 [113].