Table 2:
Mean difference (95% CI) in offspring glucose for IQR increase in total ΣAs, and geometric mean ratio (95% CI) of offspring HOMA-IR by ΣAs.
| Glucose (n = 466) | HOMA2-IR (n = 387) | |||
|---|---|---|---|---|
| Maternal ΣAs | Offspring ΣAs | Maternal ΣAs | Offspring ΣAs | |
| Model 1 | 7.83 (0.01, 15.65) | 5.40 (−1.75, 12.55) | 1.04 (0.92, 1.17) | 0.93 (0.84, 1.03) |
| Model 2 | 6.79 (−0.70, 14.28) | 4.73 (−2.30, 11.75) | 1.00 (0.90, 1.11) | 0.90 (0.81, 1.00) |
| Model 3 | 4.40 (−3.46, 12.26) | 2.72 (−4.91, 10.34) | 1.04 (0.93, 1.16) | 0.89 (0.80, 0.99) |
| Model 4 | 2.12 (−4.36, 8.59) | 4.88 (−2.07, 11.84) | 1.02 (0.93, 1.13) | 0.96 (0.87, 1.07) |
| Model 5 | 1.68 (−4.82, 8.18) | 4.25 (−2.68, 11.18) | 1.01 (0.93, 1.11) | 0.95 (0.86, 1.04) |
Model 1 is adjusted for offspring sex and age at baseline visit, and maternal eGFR at baseline for maternal models or offspring eGFR for offspring models
Model 2 = Model 1 + maternal BMI (kg/m2) and maternal fasting glucose (mg/dL) at baseline
Model 3 = Model 2 + offspring ΣAs in maternal models or maternal ΣAs in offspring models (fully adjusted model)
Model 4 = Model 3 + offspring BMI at baseline
Model 5 = Model 3 + offspring waist circumference at baseline
Geometric mean ratios (95% CI) are reported per an increase equal to the IQR in ΣAs distribution.
Generalized estimation equations (GEE) used to account for family clustering.