Table 3.

Multivariable analyses for risk of symptomatic venous thromboembolism (n = 294).

Variables	n	Univariable			Multivariable Model#1^a			Multivariable Model #2^b
		OR	(95%CI)	p	OR	(95%CI)	p	OR	(95%CI)	p
Age
< 10 years	177	1.0		0.083	1.0		0.610	1.0		0.197
≥10 years	117	2.0	(0.91, 4.5)		0.64	(0.12, 3.3)		1.7	(0.76, 3.9)
Sex								Excluded
Female	131	1.0		0.990	1.0		0.338
Male	163	1.0	(0.45, 2.2)		0.65	(0.27, 1.6)
Ethnicity								Excluded
Non-Hispanic	68	1.0		0.721	1.0		0.404
Hispanic	226	0.85	(0.34, 2.1)		0.66	(0.25, 1.7)
Treatment intensity								Excluded
NCI SR B-ALL	137	1.0		0.059	Omitted due to collinearity
NCI HR B-ALL/T-ALL	157	2.2	(0.94, 5.2)
Induction type								Excluded
3-drug, Dex	137	1.0		0.124	1.0		0.315
4-drug, Dex	26	1.0	(0.26, 6.4)		1.1	(0.20, 5.6)
4-drug, Pred	131	2.4	(0.99, 5.8)		3.3	(0.59, 18)
Weight category at diagnosis^c
Normal	188	1.0		0.008^d	1.0		0.008^d	1.0		0.015^d
Overweight	42	1.1	(0.29, 4.1)		1.1	(0.28, 4.1)		1.1	(0.30, 4.1)
Obese	64	3.4	(1.4, 7.9)		3.8	(1.5, 9.6)		3.1	(1.3, 7.3)

Multivariable model #1 includes all candidate variables.

Multivariable Model #2 is a minimal model from stepwise reverse selection (retention p ≤ 0.20). See methods for additional detail.

According to CDC age/sex norms, body mass index percentile; normal ≤85%, overweight 85– < 95%, obese ≥ 95%, OR = Odds ratio, 95%CI = 95% Confidence Interval, NCI = National Cancer Institute, Dex = dexamethasone, Pred = prednisone.

p-Value from trend test.