Fig. 3.

Alpha camera imaging of microtumors at 4 h after i.p. injection of ²¹¹At-farletuzumab (170 kBq/mL). Panel B shows an alpha image. Panel A shows the corresponding white-light photo of the imaged section, with the hot-spot areas from the alpha image superimposed. The white box in panel A is shown in panel C at 40× magnification. The ROI in red (panel B) outlines the spleen and the bright spots correspond to uptake in microtumors on the peritoneal lining of the spleen. The color-coded scale bar indicates quantified activity per cell (Bq/cell). The microtumor sizes (radius, mean ± S.D.) were 44 (±19) μm with a range from 19 to 82 μm. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)