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Long non-coding RNA biogenesis and functions. Long non-coding RNAs are transcribed by RNA polymerase II and are processed to mature RNA by the same method as protein-coding mRNAs as detailed in the text. The considerable functions of lncRNAs are: chromatin modification, transcriptional activation/suppression, sponge, and scaffold. The functions of lncRNAs depend on the type of lncRNAs. lncRNA, long non-coding RNA; RNP, ribonucleoprotein.
