Table 2.

LncRNA expression changes in postmortem brain of suicide subjects.

Brain areas and blood source	Sample size	Methods	lncRNA expression changes		lncRNA functions and roles in disease conditions	Citations
			Upregulation	Downregulation
ACC	26 MDD suicide and 24 Controls	RNA-seq and qPCR validation	SNORD3C, LLNLF-65H9.1, RP1-269M15.3, AC006003.3, AC012507.3, AC013460.1, C9orf106, DYX1C1-CCPG1, RP1-63G5.5, RP11-1186N24.5, RP11-1391J7.1, RP11-143K11.5, RP11-273G15.2, RP11-434C1.1 ZNF833P	RP11-453F18_B.1, RP11-96D1.10, AC004019.18, CTC-487M23.5, CTD-2647L4.4, RP11-326G21.1, RP11-326I11.3, RP11-326I11.5	The target genes Interferon regulatory factor 2 (IRF2, NM_002199), Lymphocyte antigen 6E (LY6E, NM_002346), and heme oxygenase (decycling) 1 (HMBOX1, NM_002133) (RP11-326I11.3, RP11-273G15.2, and CTD-2647L4.4) were successfully validated by qPCR	(79)
dlPFC	101 non-suicide, 50 non-violent suicide, 77 violent suicide (SCZ, MDD, and BD)	RNA-seq	LINC01268		Violent suicide group and aggressiveness group had higher expression of LINC01268	(28)
dlPFC	77 non-suicide, 13 non-violent suicide, and 16 violent suicide (SCZ)	RNA-seq			LOC285758 expression was associated with violent suicide	(80)
PBMC	63 MDD non-suicidal ideation, 57 MDD suicidal ideation, and 63 Controls	qPCR		TCONS_00019174, ENST00000566208, NONHSAG045500, ENST00000517573, NONHSAT034045, NONHSAT142707		(30)

ACC, Anterior Cingulate Cortex; BD, Bipolar Disorder; dlPFC, dorsolateral prefrontal cortex; lncRNA, long non-coding RNA; MDD, Major Depressive Disorder; PBMC, Peripheral Blood Mononuclear Cell; SCZ, Schizophrenia.