Table 4.
miRNA expression changes in postmortem brain and blood samples of suicide subjects.
| Brain areas | Sample size | Methods | miRNA expression changes | Successfully validated miRNAs by qPCR | miRNA roles and other findings | Citations | |
|---|---|---|---|---|---|---|---|
| Upregulation | Downregulation | ||||||
| BA9 | 18 MDD suicide and 17 Controls | TLDA | miR-142-5p, -137, -489, -148b, -101, -324-5p, -301a, -146a, -335, -494, -20b, -376a*, -190, -155, -660, -130a, -27a, -497, -10a, -20a, -142-3p | DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3b) protein expression was significantly correlated with miR-148b expression | (143) | ||
| BA9 | 10 MDD suicide and 9 Controls | qPCR | miR-30a, -30e | miR-200a | (144) | ||
| BA10 | 15 SCZ (4 suicide), 15 MDD (7 suicide), 15 BD (9 suicide), and 15 Controls | TLDA | miR-376a, -625 | miR-152, -181a, -330-3p, -34a, -133b | miR-17-5p, -145-5p, -219-2-3p | Synaptosome samples | (145) |
| BA10 | 38 suicide (4 SCZ, 23 MDD, 1 BD, and 6 subjects who did not have psychopathology) and 17 Controls | qPCR | miR-185*, 491-3p | TrkB-T1 (TrkB isoform) is a potential target of miR-185* validated by in vitro experiments | (146) | ||
| BA44 | 15 MDD suicide and 16 Controls | qPCR | miR-139-5p, -195, -320c, -34c-5p | There were significantly correlations (miR-34c-5p and miR-320c vs Diamine acetyltransferase 1 [SAT1, NM_002970]; miR-139-5p and miR-320c vs Spermine oxidase [SMOX, NM_001270691]) | (105) | ||
| BA44 | 1st set (24 MDD suicide and 35 Controls) 2nd set (11 MDD suicide and 12 Controls) |
qPCR | miR-218 | Deleted in Colorectal Carcinoma (DCC, NM_005215) is a potential target of miR-218 | (147) | ||
| BA46 | 12 MDD non-suicide, 14 MDD suicide, and 12 Controls | qPCR | miR-19a-3p | The upregulation of miR-19a-3p was also found in PBMC | (29) | ||
| LC | 9 MDD suicide and 10 Controls | TLDA | miR-17-5p, -20b-5p, -106a-5p, -330-3p, -541-3p, -582-5p, -890, -99-3p, -550-5p, -1179 | let-7g-3p, miR-409-5p, -1197 | (148) | ||
| Edinger-Westphal nucleus | 16 MDD suicide and 21 Controls | qPCR | miR-511 | GDNF family receptor alpha-1 (GFRα1, NM_001145453) is a potential target of miR-511 validated by in vitro experiment | (149) | ||
| vPFC | 32 MDD suicide and 20 Controls | qPCR | miR-425-3p, -146-5p, -24-3p, -425-3p | Four miRNAs are associated with MAPK/Wnt signaling pathways | (150) | ||
| Leukocytes | 10 MDD with suicidal ideation, 22 MDD without ideation, and 32 Controls | qPCR | miR-34b-5p and -369-3p | (151) | |||
ACC, Anterior Cingulate Cortex; BA, Brodmann area; BD, Bipolar Disorder; LC, Locus Coeruleus; miRNA, microRNA; MDD, Major Depressive Disorder; PBMC, Peripheral Blood Mononuclear Cells; SCZ, Schizophrenia; TLDA, TaqMan Low Density Arrays; vPFC, Ventrolateral Prefrontal Cortex.