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. 2020 Sep 15;7:529. doi: 10.3389/fmed.2020.00529

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Copyright © 2020 Franke, Irwin, Bayer, Brenner, Beindorff, Bouter and Bouter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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¹⁸F-Florbetaben uptake in 7-and 12-month-old WT and 5XFAD mice. (A) 7-month-old 5XFAD mice showed a significantly higher SUVr in the whole brain compared to age-matched WT mice. (B) 12-month-old 5XFAD mice showed significantly higher SUVr in the whole brain compared to age-matched WT mice. (C) 7-month-old 5XFAD mice showed a significantly higher SUVr in all tested brain regions compared to age-matched WT mice except for the olfactory bulb region. (D) Significant differences in 12-month-old mice were also detected in all analyzed brain regions except for the olfactory bulb. Unpaired t-test; *p < 0.05; **p < 0.01; ***p < 0.0001; data presented as mean +/- SEM.