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. 2020 Sep 15;7:529. doi: 10.3389/fmed.2020.00529

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Copyright © 2020 Franke, Irwin, Bayer, Brenner, Beindorff, Bouter and Bouter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial reference memory deficits in 5XFAD mice in the Morris water maze. (A) 7-month-old WT and 5XFAD mice showed no memory deficits in the probe trial. (C) At 12 months of age male 5XFAD showed no quadrant preference revealing an impaired spatial reference memory. In contrast, 12-month-old WT animals displayed an intact reference memory. (B,D) Swimming speed was not altered at any of the tested time points. (A,C) One-way ANOVA followed by Bonferroni multiple comparisons. (B,D) Unpaired t-test; ***p < 0.0001; T, target quadrant; L, left quadrant; R, right quadrant; O, opposite quadrant; data presented as mean +/- SEM.