Table 1.
Pharmacokinetic parameters of R-warfarin and S-warfarin after oral administration of warfarin (0.2 mg/kg) alone and co-administration with RVT (100 mg/kg) at 0.5 h before warfarin. Each group included 8 rats.
| Parameter | Treatment | |
|---|---|---|
| Warfarin alone | Warfarin + RVT | |
| R-warfarin | ||
| Cmax (ng/mL) | 315.1 ± 53.4 | 482.7 ± 49.0 |
| AUC0−24 (h·ng/mL) | 4471.1 ± 546.4 |
7089.3 ± 842.6* + 58.6% |
| AUC0−t (h·ng/mL) | 5758.8 ± 672.0 |
8931.2 ± 1466.5 + 55.1% (p = 0.07) |
| MRT0−t (h) | 13.4 ± 1.1 | 11.6 ± 1.2 |
| S-warfarin | ||
| Cmax (ng/mL) | 489.5 ± 76.1 | 672.0 ± 61.0 |
| AUC0−24 (h·ng/mL) | 7128.3 ± 837.6 |
10,605.7 ± 829.4* + 48.8% |
| AUC0−t (h·ng/mL) | 10,563.9 ± 1054.5 |
15,009.5 ± 1749.0* + 42.1% |
| MRT0−t (h) | 17.2 ± 0.9 | 15.0 ± 1.0 |
Data expressed as mean ± SEM *p < 0.05.
Cmax, maximum concentration.
AUC0−24, area under concentration–time curve from 0 to 24 h.
AUC0−t, area under concentration–time curve to the last time.
MRT0−t, mean residence time from the time of dosing to the time of last measurable concentration.