Table 5.
The effects of combined two factors (P4 ratio and P4 level I) on the outcomes of assisted reproduction technology cycles for the patients with high P4 levels on the day of hCG injection (n = 149).
| P4 level I | ≤0.975 | >0.975 | |
|---|---|---|---|
| P4 ratio | >1.62 | ≤1.62 | >1.62 |
| Group | A | B | C |
| N (patients, cycles) | 64 | 60 | 25 |
| Age (years) | 33.3 ± 3.4 | 33.1 ± 3.6 | 32.8 ± 3.5 |
| P4 level II (ng/ml, hCG day) | 2.78 ± 1.32a | 2.02 ± 0.88a,b | 3.10 ± 1.39b |
| P4 ratio | 6.2 ± 5.8c,d | 1.2 ± 0.3c,e | 2.3 ± 1.0d,e |
| LH (mIU/ml, hCG day) | 2.6 ± 1.8 | 2.3 ± 1.6 | 3.1 ± 1.4 |
| Estradiol (pg/ml, hCG day) | 1,944 ± 1,004f | 2,441 ± 905f | 1,989 ± 1,070 |
| Total FSH dosage | 2,802 ± 912 | 2,880 ± 565 | 2,808 ± 720 |
| Oocyte number | 9.5 ± 3.6 | 11.0 ± 3.2 | 10.6 ± 3.5 |
| Mature oocyte no. | 7.5 ± 3.5 | 8.3 ± 3.2 | 8.1 ± 3.1 |
| Total embryo no. | 6.0 ± 3.0 | 6.3 ± 2.8 | 6.0 ± 2.4 |
| Day 3 good embryo rate | 64.8 ± 27.0 | 62.2 ± 25.0 | 66.6 ± 30.5 |
| ET no. | 3.1 ± 0.7 | 3.1 ± 0.6 | 3.2 ± 0.7 |
| Implantation rate | 30.8 (61/198)g | 10.3 (19/184)g,h | 25.3 (20/79)h |
| Pregnancy rate | 67.2 (43/64)i,j | 20.0 (12/60)i | 40.0 (10/25)j |
| Abortion rate | 23.3 (10/43) | 16.7 (2/12) | 40.0 (4/10) |
| Live birth rate | 51.6 (33/64)k,l | 15.0 (9/60)k | 24.0 (6/25)l |
| Gestational age (weeks) | 37.0 ± 2.3 | 37.7 ± 1.5l | 35.2 ± 1.8k,l |
| Birth weight (g) | 2,732 ± 684 | 2,821 ± 477 | 2,194 ± 551 |
Statistical methods: Kruskal-Wallis test, χ2 test and Fisher's exact test (
a
p = 0.026;
d
p = 0.026;
f
p = 0.014;
h
p = 0.002;
j
p = 0.030;
b,c,e,g,i,k
p < 0.001;
l
p = 0.031).
In the table, percentages are used to describe categorical data and mean ± SD used to describe a set of continuous data.
P4 level I: 2 days before the day of hCG administration; P4 level II: progesterone level on the day of hCG administration; FSH, follicle stimulating hormone; E2, estrogen; LH, luteinizing hormone; P4, progesterone; ET, embryo transfer; MII, oocyte with metaphase II.