Table 1.
Characteristics of tumour-infiltrating immune cells (TIICs) in the study group regarding nuclear grade of DCIS. Data presented as medians, interquartile ranges in brackets. Units for each variable are included in square brackets. Groups were compared using Kruskal–Wallis test. Bold values denote statistical significance.
| Feature | Whole group (n = 75) | Nuclear Grade 1 (n = 24) | Nuclear Grade 2 (n = 34) | Nuclear Grade 3 (n = 17) | p-Value |
|---|---|---|---|---|---|
| TIICs infiltration quantified in H&E [%] | 1.0 (1.0–5.0) |
1.0 (1.0–1.0) |
5.0 (1.0–5.0) |
5.0 (5.0–10.0) |
<0.001 |
| CD4 [number/mm2] | 43.0 (21.0–106.0) |
30.0 (11.0–46.5) |
50.0 (26.0–120.0) |
63.5 (36.0–171.0) |
0.010 |
| CD8 [number/mm2] | 49.0 (28.0–91.0) |
34.0 (21.0–65.0) |
54.0 (31.0–102.0) |
89.5 (25.5–144.0) |
0.062 |
| CD4/CD8 ratio | 0.9 (0.6–1.5) |
0.8 (0.3–1.2) |
1.0 (0.7–1.6) |
1.0 (0.7–1.7) |
0.157 |
| CD68 [number/mm2] | 20.0 (9.0–34.0) |
18.0 (6.5–36.0) |
25.5 (11.0–38.0) |
15.0 (8.0–20.5) |
0.397 |
| CD163 [number/mm2] | 9.0 (3.0–16.0) |
5.0 (1.0–13.0) |
11.0 (3.5–22.0) |
7.5 (2.5–14.0) |
0.123 |
| CD68/CD163 ratio | 2.3 (1.2–5.2) |
3.2 (1.9–6.3) |
2.3 (1.1–4.3) |
1.7 (1.1–7.0) |
0.225 |
| FOXP3 [number/mm2] | 4.0 (1.0–15.0) |
4.0 (1.0–11.0) |
8.0 (1.0–22.5) |
1.0 (0.0–10.0) |
0.089 |