Table 2.
Characteristics of tumour-infiltrating immune cells (TIICs) in the study group divided by HER2 expression. Data presented as medians and interquartile ranges in brackets. Units for each variable are included in square brackets. Groups were compared using Kruskal–Wallis test. Bold values denote statistical significance.
| Feature | Whole group (n = 75) | HER2-0 (n = 18) |
HER2-1 (n = 11) |
HER2-2 (n = 39) |
HER2-3 (n = 7) |
p-Value |
|---|---|---|---|---|---|---|
| TIICs infiltration quantified in H&E [%] | 1.0 (1.0–5.0) |
5.0 (1.0–10.0) |
5.0 (5.0–30.0) |
1.0 (1.0–5.0) |
5.0 (1.0–10.0) |
0.004 |
| CD4 [number/mm2] | 43.0 (21.0–106.0) |
38.8 (17.5–105.5) |
53.5 (27.0–594.0) |
34.3 (20.0–74.0) |
107.0 (45.5–171.0) |
0.161 |
| CD8 [number/mm2] | 49.0 (28.0–91.0) |
55.3 (28.0–104.0) |
47.0 (30.0–400.5) |
41.0 (26.0–66.0) |
94.5 (25.5–144.0) |
0.277 |
| CD4/CD8 ratio | 0.9 (0.6–1.5) |
0.8 (0.4–1.2) |
1.0 (0.7–1.8) |
1.0 (0.6–1.4) |
0.9 (0.7–1.7) |
0.525 |
| CD68 [number/mm2] | 20.0 (9.0–34.0) |
12.5 (5.0–20.0) |
20.5 (9.5–38.5) |
29.5 (12.0–42.0) |
8.8 (6.0–16.0) |
0.007 |
| CD163 [number/mm2] | 9.0 (3.0–16.0) |
5.3 (1.5–10.5) |
7.5 (2.0–16.5) |
11.8 (4.5–17.5) |
6.5 (1.0–8.5) |
0.107 |
| CD68/CD163 ratio | 2.3 (1.2–5.2) |
2.5 (1.1–5.7) |
2.3 (1.6–6.0) |
2.4 (1.2–4.3) |
2.4 (1.5–6.0) |
0.924 |
| FOXP3 [number/mm2] | 4.0 (1.0–15.0) |
2.0 (0.0–11.0) |
4.5 (1.5–44.5) |
8.3 (1.0–17.0) |
0.0 (0.0–1.0) |
0.003 |