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. 2020 Sep 28;11:4878. doi: 10.1038/s41467-020-18702-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Spectrum of the key molecular alterations in PSC. The genomic alterations of smokers and nonsmokers are demonstrated in the left and right side, respectively. The overall number of somatic mutations and clinicopathological data are shown at the top. The type of base-pair substitutions of each sample are displayed in the bottom panel. b Mutational signatures in our cohort (n = 56). Samples, annotated for the histological subtype, smoking status and tumor mutation burden, are ordered by the contribution of signature 4. Source data are provided as a Source data file.