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. 2020 Sep 28;11:4878. doi: 10.1038/s41467-020-18702-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Columns depict the proportion of shared and specific somatic mutations of the 14 tumors microdissected. b Clonality indices for the 14 cases of PSC, suggesting the likelihood of common origin of the two components. Black dotted lines represent the cut-off value of clonality index to define clonal relatedness. c The distribution of copy number variations (CNVs) for all PSC samples microdissected. Red indicates CNV gain, and blue CNV loss. White represents the failure in CNV calling. AT, adenocarcinoma component; SCCT, squamous cell carcinoma component; ST, sarcomatoid component. Source data are provided as a Source data file. d Phylogenetic trees generated for 4 PSC samples. The length of the trunk (green) and branch (red or blue) represents the number of shared and specific nonsynonymous mutations, respectively. Part of driver mutations is marked. The number of truncal and total nonsynonymous mutations is indicated below. E and S represent epithelial and sarcomatoid component, respectively.