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. 2020 Sep 28;11:4878. doi: 10.1038/s41467-020-18702-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The percentage of PSC, LUSC, or LUAD in the two major clusters yielded by unsupervised hierarchical clustering of DNA methylation data. b The proportion of the four LUSC subtypes in three clusters of PSC. Source data are provided as a Source data file. c Boxplots show the Euclidean distance-based similarity between the DNA methylation profiles of C1 and three LUAD methylation subtypes. Source data are provided as a Source data file. d Boxplots show the Euclidean distance-based similarity between the DNA methylation profiles of C2 and three LUAD methylation subtypes. Center line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range; points, outliers. Two-sided Wilcoxon rank-sum test was used for statistical analysis of (c) and (d). No P-value adjustment was applied. Source data are provided as a Source data file.