Figure 4.

Exendin-4 suppresses subcutaneous tumor formation in nude mice. PANC-1 cells or/and PSCs were subcutaneously injected into nude mice. One week later, the mice were intraperitoneally administered with exendin-4 daily for three weeks. (A) Photograph of xenograft tumor masses. (B) Volume of xenograft tumors (*P<0.05, by Student’s t-test). (C) Weight of xenograft tumors (**P<0.01, by Student’s t-test vs PANC-1; ^&&P<0.01, by Student’s t-test vs PANC-1+PSC). (D) Immunostaining for Ki67, Coll-I and α-SMA in tumor tissues (**P<0.01, by Student’s t-test vs PANC-1; ^&&P<0.01, by Student’s t-test vs PANC-1+PSC). All results were analyzed using Student’s t-test. Data represent mean ± SD from three independent experiments.