Figure 1.

The Landscape of Immuno-cell Infiltration in the TME of HNSC

(A) Unsupervised clustering of tumor-infiltrating immune cells in five independent HNSC cohorts. Rows represent tumor-infiltrating immune cells, and columns represent samples. (B) Kaplan-Meier curves for overall survival (OS) of all HNSC patients with immune cell-infiltrating classes. Log rank test showed an overall p = 0.018. (C) The fraction of tumor-infiltrating immune cells in three ICI clusters. We also plotted the immune score and stromal score of three ICI clusters. The statistical difference of three ICI clusters was compared through the Kruskal-Wallis test. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001. (D) Cellular interaction of the tumor-infiltrating immune cell types. (E and F) Difference in PD-L1 (E) and PD1 (F) expression among distinct ICI clusters (Kruskal-Wallis test, p < 0.0001).