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. 2020 Sep 15;11:1022. doi: 10.3389/fgene.2020.01022

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Copyright © 2020 Panahi, Rodriguez, Fereshtehnejad, Arafa, Bogdanovic, Winblad, Cedazo-Minguez, Rinne, Darreh-Shori, Hase, Kalaria, Viitanen and Behbahani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GLUT2 immunoreactivity in cerebral microvessels in CADASIL. Immunofluorescent labeling of GLUT2 (green), smooth muscle α-actin (SMA; red) and arteries and arterioles in the frontal white matter, counterstained with DAPI (A,B). Sections from panel (A) a 94-year-old non-demented female control and (B) 68-year-old female CADASIL case with p.Arg133Cys mutation. Severe capillary degeneration was observed in CADASIL (B), with low GLUT2 expression observed in VSMCs compared to control subject. There was minimal SMA immunoreactivity in capillaries in CADASIL. Scale bar = 20 μm in panels (A,B). (C) Quantification of GLUT2 expression demonstrated significantly lower GLUT2 expression in CADASIL brain tissues as compared to controls (**p < 0.01). CADASIL: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.