Table 3.
Concentration of unformulated curcumin in plasma, serum, and various tissues of rats and humans after different routes of administration (PO, IP, and IV).
| Species | Route | Dose | Concentration of unformulated curcumin in the plasma, serum and various tissues | Reference | ||
|---|---|---|---|---|---|---|
| Plasma | ||||||
| Rat | PO | 1000 mg/kg | 15 ng/mL | (Prasad et al., 2014) | ||
| 500 mg/kg | 60 ng/mL | (Yang et al., 2007) | ||||
| 100mg/kg | 220 ng/mL | (Pan et al., 1999) | ||||
| IP | 100mg/kg | 2250 ng/mL | (Pan et al., 1999) | |||
| 100mg/kg | 2 nmol/mL | (Perkins et al., 2002) | ||||
| IV | 10 mg/kg | 360 ng/mL | (Yang et al., 2007) | |||
| 2 mg/kg | 6600 ng/mL | (Sun et al., 2013a) | ||||
| Human | PO | 4000-8000 mg | 410-1750 nM | (Cheng et al., 2001) | ||
| 3600 mg | 11.1 ng/mL | (Sharma et al., 2004) | ||||
| Serum | ||||||
| Rat | PO | 2000mg/kg | 1350 ng/mL | (Shoba et al., 1998) | ||
| 1000mg/kg | 500 ng/mL | (Maiti et al., 2007) | ||||
| 340 mg/kg | 6.5 nM | (Marczylo et al., 2007) | ||||
| Human | 12000 mg | 51.2 ng/mL | (Lao et al., 2006) | |||
| 10000 mg | 50.5 ng/mL | (Lao et al., 2006) | ||||
| 4000-8000 mg | 400-3600 nM | (Cheng et al., 2001) | ||||
| 2000 mg/kg | 6 ng/mL | (Shoba et al., 1998) | ||||
| 400-3600 mg | 7-20 nmol/g | (Garcea et al., 2005) | ||||
| Gastrointestinal (GI) tract | ||||||
| Rat | PO | 2000mg/kg | Averaged GI tract concentration | |||
| 42125 ng/g | Small intestine | 58600 ng/g | (Ravindranath and Chandrasekhara, 1980) | |||
| Stomach | 53300 ng/g | (Ravindranath and Chandrasekhara, 1980) | ||||
| Cecum | 51500 ng/g | (Ravindranath and Chandrasekhara, 1980) | ||||
| Large intestine | 5100 ng/g | (Ravindranath and Chandrasekhara, 1980) | ||||
| Intestine | ||||||
| IP | 100mg/kg | 117040 ng/g | (Pan et al., 1999) | |||
| Intestinal mucosa | ||||||
| IP | 100mg/kg | 200 nmol/g | (Perkins et al., 2002) | |||
| Other organs and tissues | ||||||
| Rat | IP | 100mg/kg | Liver | |||
| 26900 ng/g | (Pan et al., 1999) | |||||
| 73 nmol/g | (Perkins et al., 2002) | |||||
| Spleen | ||||||
| 26010 ng/g | (Pan et al., 1999) | |||||
| Kidney | ||||||
| 7510 ng/g | (Pan et al., 1999) | |||||
| 78 nmol/g | (Perkins et al., 2002) | |||||
| Lungs | ||||||
| 16 nmol/g | (Perkins et al., 2002) | |||||
| Heart | ||||||
| 9.1 nmol/g | (Perkins et al., 2002) | |||||
| Muscle | ||||||
| 8.4 nmol/g | (Perkins et al., 2002) | |||||
| Brain | ||||||
| 400 ng/g | (Pan et al., 1999) | |||||
| 2.9 nmol/g | (Perkins et al., 2002) | |||||