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. 2020 Sep 15;7:546. doi: 10.3389/fmed.2020.00546

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Copyright © 2020 Fernandes, Vale, Guzen, Pinheiro, Cobucci and de Azevedo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of action of nucleoside analogs (Remdesivir) through inhibition of RNA-dependent RNA polymerase (RdRp). (A) Entry of SARS-CoV-2 into the cell, (B) Formation of the endosome, (C) Release of viral RNA in the cell's cytoplasm, (D) Viral self-replication by RdRp, (E) Synthesis of virus structural proteins, (F) Incorporation of RNA viral, (G) New viral units, (H) Release of new viruses, and (I) Inhibition of viral self-replication by RdRp. Figure source: Authors' own drawing.