Table 3.

Pharmacokinetic profiles of after GemHCl and 4NSG were administered intravenously to mice.

Parameter	Unit	One-compartment model		Significance level p-value
		GemHCl	4NSG
K10	1/h	1.01 ± 0.03	0.36 ± 0.04	0.0001
t1/2	h	0.70 ± 0.01	1.93 ± 0.06	0.0001
Vd	mL	21.7 ± 1.9	19.3 ± 0.2	0.3619
CL	mL/h	21.3 ± 3.2	7.1 ± 1.1	0.0001
AUC (0-t)	μg/(mL * h)	28.2 ± 4.3	86.2 ± 5.4	0.0001
AUMC(0-inf)	μg/(mL * h2)	28.2 ± 4.1	86.6 ± 4.8	0.0001
MRT	h	1.2 ± 0.1	2.8 ± 0.4	0.02
Vss	μg/(μg/mL)	21.7 ± 3.6	23.9 ± 1.6	ns

k₁₀, elimination rate constant; t_1/2, half-life; AUC_(0-t),area under the plasma concentration–time curve; AUMC_(0-inf), area under the first moment curve; MRT, mean residence time; Cl, clearance; V_d, volume of distribution; V_ss, volume of distribution at steady state. (Data analyzed using t-test).