Table 5.
The Effect of Different HR-HPV Genotypes Model in Triaging Women with ASC-US. (N=2393)
| HR-HPV Genotypes Model | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Referral Ratea % (n/N) |
|---|---|---|---|---|---|
| HR-HPVb | 95.0 (92.3–97.8) | 57.7 (55.7–59.8) | 20.2 (18.1–22.7) | 99.0 (98.5–99.6) | 47.6 (1139/2393) |
| HPV16/18c | 54.1 (47.9–60.4) | 91.7 (90.6–92.9) | 42.4 (36.5–47.5) | 94.7 (93.3–95.3) | 12.9 (309/2393) |
| HPV16/18/58d | 71.9 (66.2–77.6) | 85.4 (83.9–86.9) | 35.7 (31.1–39.6) | 96.4 (95.1–96.9) | 20.4 (488/2393) |
| HPV16/18/52/58e | 83.9 (79.3–88.5) | 73.6 (71.7–75.5) | 26.3 (22.9–29.1) | 97.6 (96.2–97.8) | 32.2 (771/2393) |
| HPV16/18/33/52/58f | 87.6 (83.5–91.8) | 71.6 (69.7–73.5) | 25.8 (22.5–28.5) | 98.1 (96.7–98.2) | 34.4 (823/2393) |
| HPV16/18/31/33/52/58g | 91.3 (87.8–94.9) | 70.0 (68.1–72.0) | 25.5 (22.4–28.2) | 98.6 (97.3–98.7) | 36.2 (866/2393) |
Notes: aThe rate of referred to colposcopy in ASC-US women; ball women with any positive of HPV16, HPV18, HPV 31, HPV 33, HPV 35, HPV 39, HPV 45, HPV 51, HPV 52, HPV 56, HPV 58, HPV 59, HPV 66 and HPV68 were directly referred to colposcopy and biopsy; cwomen with HPV16 and/or HPV18 infection directly referred to colposcopy and biopsy; dall women with any positive of HPV16, HPV18, and HPV58 were directly referred to colposcopy and biopsy; eall women with any positive of HPV16, HPV18, HPV52 and HPV58 were directly referred to colposcopy and biopsy; fall women with any positive of HPV16, HPV18, HPV33, HPV52 and HPV58 were directly referred to colposcopy and biopsy; gall women with any positive of HPV16, HPV18, HPV31, HPV33, HPV52 and HPV58 were directly referred to colposcopy and biopsy.
Abbreviations: HR-HPV, high-risk human papillomavirus, including types HPV-16, −18, −31, −33, −35, −39, −45, −51, −52, −56, −58, −59, −66, −68; PPV, positive predictive value; NPV, negative predictive value.