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. 2020 Sep 15;10:1482. doi: 10.3389/fonc.2020.01482

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Copyright © 2020 Song, Sun, Duan, He, Wu, Huang, Xing, Sun, Wang, Xie, Mao, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SYPL1 was upregulated in pancreatic ductal adenocarcinoma (PDAC). (A) SYPL1 was upregulated in PDAC at the transcription level (GSE15471, GSE16515, GSE28735, TCGA, and GTEx datasets were used). (B) The expression of SYPL1 in tumor and pancreatic acini at the protein level. Tissue sections from three PDAC patients were used as examples. (C) Quantification of SYPL1 protein levels in 42 paired tumor sections and pancreatic acini sections. (D) Quantification of SYPL1 RNA in PDAC cell lines (BXPC-3, CFPAC-1, and PANC-1) and immortal human pancreatic duct epithelial cell lines HPDE6-C7. (E) SYPL1 protein levels in cell lines. *p < 0.05, ***p < 0.001 and ****p < 0.0001.