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. 2020 Sep 15;10:1482. doi: 10.3389/fonc.2020.01482

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Copyright © 2020 Song, Sun, Duan, He, Wu, Huang, Xing, Sun, Wang, Xie, Mao, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SYPL1 promoted cell proliferation. (A) Western blotting showed knockdown and overexpression of SYPL1 in BXPC-3 and PANC-1 cells. (B) CCK8 assay showed that knockdown of SYPL1 suppressed cell proliferation and vice versa. (C) Colony formation assay showed that knockdown of SYPL1 significantly reduced the colony formation ability and vice versa. (D) Suppression of SYPL1 significantly inhibited tumor growth as determined by a subcutaneous xenograft mouse model. (E) Tumor weight of the indicated cells after nude mice were sacrificed. (F) Curves of tumor diameter after the indicated cells were implanted in the subcutaneous xenograft mouse model. *p < 0.05, **p < 0.01 and ****p < 0.0001.