Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 15;10:1482. doi: 10.3389/fonc.2020.01482

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Song, Sun, Duan, He, Wu, Huang, Xing, Sun, Wang, Xie, Mao, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SYPL1 protected cells from apoptosis. (A) GSEA analysis showed that the expression of SYPL1 was related to the KEGG apoptosis pathway in the TCGA dataset. (B) In the TCGA and PACA-AU dataset, the mutation rates of KRAS, TP53, CDKN2A, and SMAD4 tended to be higher in SYPL1-high patients. (C) The expression of SYPL1 positively correlated with BIRC5, XIAP, MCL1, BCL2L1, PIK3CB, CFLAR, and CAPN2, which were reported as anti-apoptosis genes. (D) Flow cytometry showed that overexpression of SYPL1 protected cells from apoptosis, and vice versa. *p < 0.05 and **p < 0.01.