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. 2020 Sep 15;11:561306. doi: 10.3389/fphar.2020.561306

Figure 1.

Figure 1

Ubc9 improves cardiac function and alleviates left ventricular remodeling after MI Adv-Ubc9 or Adv-Null was multipoint injected around the ligature of the heart in C57BL/6 mice immediately after MI. (A) Representative M-mode images; quantitative analysis of LVIDs, LVIDd, LVAWs, LVAWd, LVPWs, LVPWd, FS, and EF values are presented at day 14 post-MI, n = 5–8 per group. (B) Representative images and quantitative analysis of Masson trichrome staining at day 14 post-MI, n = 5 per group. (C) Representative images and quantitative analysis of TUNEL-positive cells (red), nuclear cells (DAPI, blue), and cardiomyocytes (α-Actinin, green) at day 5 post-MI; arrows point to apoptotic cells, n = 5 per group. (D, E) Western blotting analysis of Ubc9 and Cleaved caspase3 in the border and the infarct area at day 5 post-MI, n = 5–8 per group. Data were analyzed by one-way ANOVA, followed by a Bonferroni post-hoc test.