Fig. 4.

Mood stabilizers and mt protein or pathway targets, as well as the schematic of precision psychiatry medicine. (A) Physical connectivity of NPD-linked mt proteins that are targets of the mood stabilizers. (B) Enriched (see Supplemental Table S6 for Benjamini-Hochberg FDR adjusted p-value) mt pathways targeted alone or shared by the mood stabilizers. (C) NPD-associated mt proteins targeted by one or more mood stabilizing medications (panel i) are highlighted (panel ii-iv) with their interacting partners as sub-networks. (D) Precision psychiatry model is shown by integrating various data features, which is fed into AI (or machine learning) algorithms to stratify and identify best therapeutic treatment for each subject through patient matching to evaluate treatment response and disease prognosis (see main text).