Table 3.
Characteristics of those with and without transaminitis
| Transaminitis (n = 73) | No transaminitis (n = 57) | P value | |
| Age, yr, median (IQR) | 63 (48, 72) | 62 (48, 76) | 0.9 |
| Females | 31 (42.5) | 28 (49.1) | 0.4 |
| Body mass index, kg/m2, median (IQR) | 30.2 (26.5, 36.8) | 27.3 (24.5, 33.2) | 0.04 |
| Smoking | 19 (26) | 19 (33.3) | 0.4 |
| Alcohol | 20 (27.4) | 10 (17.5) | 0.2 |
| Diarrhea | 24 (32.9) | 10 (17.5) | 0.05 |
| Nausea | 18 (24.7) | 14 (24.6) | 1.0 |
| Abdominal pain | 11 (15.1) | 10 (17.5) | 0.7 |
| Anorexia | 19 (26) | 15 (26.3) | 1.0 |
| Other gastro-intestinal symptoms1 | 19 (26) | 18 (31.6) | 0.5 |
| X-ray findings2 | 55 (75.3) | 32 (56.1) | 0.02 |
| Hypertension | 38 (52.1) | 31 (54.4) | 0.8 |
| Age-adjusted Charlson Index, median (IQR) | 3 (1, 6) | 4 (1, 6) | 0.7 |
| On ventilator | 31 (42.5) | 12 (21.1) | 0.01 |
| Admitted to intensive care unit | 39 (53.4) | 19 (33.3) | 0.02 |
| On medications with GI side-effects | 26 (35.6) | 20 (35.1) | 1.0 |
| Alanine aminotransferase, IU/L, median (IQR) | 48 (34, 84) | 15 (10, 20) | < 0.001 |
| Aspartate aminotransferase, IU/L, median (IQR) | 66 (42, 100) | 20 (14, 26) | < 0.001 |
| Alkaline phosphatase, IU/L, median (IQR) | 97 (66, 124) | 70 (56, 92) | < 0.001 |
| Total bilirubin, mean (SD) | 0.6 (0.3) | 0.4 (0.2) | < 0.001 |
| Albumin, g/dL, mean (SD) | 3.0 (0.8) | 3.4 (0.7) | 0.01 |
1
Other gastro-intestinal symptoms include loss of taste or smell, constipation, dysphagia, reflux and vomiting.
2
X-ray findings including ground glass opacities and bilateral infiltrate. All values are reported as n (%), mean (SD) or median (25th, 75th). P value: Chi-square test for categorical variables, two-sided t-test for parametric continuous variables and Wilcoxon rank-sum test for nonparametric continuous variables. IQR: Interquartile range; GI: Gastrointestinal.