Table 1.

Diagnostic markers for hepatocellular carcinoma

Marker	Comparison groups	Sensitivity	Specificity	AUC	Ref.
AFP	Meta-analysis	51.9	94	0.81	Xu et al[17]
AFP-L3	Meta-analysis	48.3	92.9	0.76	Yi et al[21]
DCP	Meta-analysis	71	84	0.89	Zhu et al[25]
Glypican-3	Meta-analysis	55	58	0.78	Xu et al[34]
AKR1B10	HCC vs controls	72.7	95.7	0.9	Ye et al[36]
HMGB3	HCC vs controls	75.6	85.6	0.79	Zheng et al[41]
GALAD	HCC vs controls	91.6	89.7	0.97	Berhane et al[49]

AUC: Area under the curve; AFP: Alpha-fetoprotein; AFP-L3: Isoform of AFP binding lectin L3; DCP: Des-gamma carboxyprothrombin; AKR1B10: Aldo-keto reductase family 1 member 10; HMGB3: High mobility group box 3; GALAD: Gender, Age: Lens culinaris agglutinin-reactive of alpha-fetoprotein, Alpha-fetoprotein, and Des-γ-carboxy prothrombin.