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. 2020 Sep 15;11:572983. doi: 10.3389/fgene.2020.572983

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Copyright © 2020 Zhao, Qu, Lv, Wang, Bian, Yang, Zhao, Ji, Ni, Fu, Xin and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The synergistic long non-coding RNAs (lncRNA)-microRNAs (miRNA) network in the context of colon adenocarcinoma (COAD). (A) Global view of the synergistic network. Orange and purple nodes represent lncRNAs and miRNAs, respectively. Red and green edges represent positive and negative synergistic relationships. Larger nodes represent higher degrees. (B) Statistics of nodes and edges in the synergistic network. (C) Degree distribution of the synergistic network. (D) The mean path length of the synergistic network is higher than randomization test. The arrow represents the mean path length in the real network. (E) The synergistic lncRNA–miRNA pairs with more co-regulated mRNAs show more significantly synergistic regulatory relationship. The white circles represents the outlier points in boxplots.