Table 1.
Features of HPV-negative and HPV-positive HNSCC.
| Feature | HPV− | HPV+ | References |
|---|---|---|---|
| Risk factors | Tobacco, Alcohol | HPV | (23) |
| Incidence | Decreasing | Increasing | (24) |
| Most common anatomic site | Oral cavity, Larynx | Oropharynx | (20) |
| Age | Older | Younger | (25) |
| Race | Non-Caucasian | Caucasian | (20) |
| Education level | Lower | Higher | (24) |
| 5-years overall survival | 48% | 80% | (26) |
| Histological subtype | Keratinizing | Non-keratinizing | (27) |
| LN metastases | 55.7% | 86% | (20) |
| Mutational spectrum | TP53, CDKN2A, MLL2, CUL3, NSD1, PIK3CA, NOTCH | PIK3CA, DDX3X, CYLD, FGFR | (28) |
| Density of tumor-infiltrating immune cells | Lower | Higher | (29) |
HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus; LN, lymph node.