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. 2020 Sep 17;9(9):502–515. doi: 10.1089/wound.2019.1041

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© Vimal Jacob et al., 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Evaluation of VLCM antifibrotic activity in a rabbit abdominal adhesion model. Tissues were collected at 28 days postsurgery and were evaluated macro- and microscopically for severity of postsurgical adhesion formation. Postsurgical gross evaluation of the abdominal area shows that (A) the cecum has tight adhesions to the AW at the control site (no graft, black arrows point to adhesions), (B) whereas adhesions were not detected at the site that received VLCM. Histological evaluation: (C) H&E-stained tissue sections of control and (D) VLCM-treated sites. Black arrows point to a dense collagen band formed at the control site. (E) The presence of fibrous tissue between the cecum and AW was seen in the MT-stained section of the control site. (F) There was no fibrous tissue between the cecum and AW detected at the VLCM site. AD, adhesion; AW, abdominal wall; C, cecum. (n = 4).