Mortality |
COVID-19 with different disease severity |
RR 0.92 (0.69–1.22) based on data from 10,278 patients in 9 observational studies and 1 RCT |
19.9% |
−1.6% (−6.2% to 4.4%) |
Very low (serious inconsistency and imprecision) |
We are very uncertain of the effect of corticosteroids on short term mortality in patients with COVID-19 |
Mortality |
Critical COVID-19 |
RR 0.80 (0.26–2.46) based on data from 1719 patients in 2 observational studies and 1 RCT |
52.2% |
−10.4% (−38.6% to 76.2%) |
Very low (serious inconsistency) |
We are very uncertain of the effect of corticosteroids on short term mortality in patients with critical COVID-19 |
Mortality |
Severe COVID-19 |
RR 0.98 (0.73–1.30) from 9673 patients in 6 observational studies and 1 RCT |
15.8% |
−0.3% (−4.3% to 4.8%) |
Very low (serious inconsistency) |
We are very uncertain of the effect of corticosteroids on short term mortality in patients with severe COVID-19 |
Mortality |
Non severe COVID-19 |
RR 0.67 (0.19–2.34) based on data from 1824 patients in 1 observational study and 1 RCT |
14% |
−4.6% (−11.4% to 18.8%) |
Very low (serious inconsistency) |
We are very uncertain of the effect of corticosteroids on short term mortality in patients with non-severe COVID-19 |
Composite outcome of death/ICU/MV |
Severe COVID-19 |
RR 0.41 (0.23–0.73) based on data from 676 patients in 4 observational studies |
44.1% |
−26% (−33.9% to 11.9%) |
Very low (serious inconsistency) |
We are very uncertain of the effect of corticosteroids on composite outcome of death/ICU admission/MV in patients with severe COVID-19 |
Mechanical ventilation need |
Severe COVID-19 |
RR 0.74 (0.50–1.09) based on data from 5768 patients in 2 observational studies and 1 RCT |
9.3% |
−2.4% (−4.7% to 0.8%) |
Very low (serious inconsistency) |
We are very uncertain of the effect of corticosteroids on mechanical ventilation need in patients with severe COVID-19 |
Delayed viral clearance |
COVID-19 with different disease severity |
RR 1.47 (1.11–1.93) based on data from 760 patients in 6 observational studies |
20.7 % |
9.7% (2.3%–19.2%) |
Low |
Corticosteroids may delay viral clearance in patients with COVID-19 |
Acquired blood stream infections |
COVID-19 with different disease severity |
HR 3.95 (1.20–13.03) based on data from 78 patients in 1 observational study |
45.5% |
45.4% (6.2%–54.5%) |
Very low (serious inconsistency) |
Corticosteroids probably do increase the risk of acquired blood stream infections in patients with COVID-19 |