Table 2.

Characterization of all polymorphisms in NLRP3 and CASP1, included in analysis of study.

Gene	CHR	SNP	A1	A2	MAF	FUNCTION	RegulomeDB
NLRP3	1	rs56383829	T	C	0.49	intron variant	5
NLRP3	1	rs3806265	C	T	0.47	intron variant	5
NLRP3	1	rs10159239	G	A	0.39	intron variant	5
NLRP3	1	rs12137901	C	T	0.30	intron variant, upstream variant 2 KB	4
NLRP3	1	rs12130711	T	C	0.28	intron variant	1f
NLRP3	1	rs4925659	A	G	0.28	intron variant	4
NLRP3	1	rs10925023	T	G	0.28	intron variant	7
NLRP3	1	rs200927356	G	A	0.27	intron variant	5
NLRP3	1	rs72553860	G	A	0.26	intron variant, upstream variant 2 KB	4
NLRP3	1	rs4925650	A	G	0.26	intron variant	7
NLRP3	1	rs4378247	C	T	0.24	intron variant	3a
NLRP3	1	rs12565738	T	C	0.24	intron variant	5
NLRP3	1	rs4925654	A	G	0.21	intron variant	6
NLRP3	1	rs12728998	T	C	0.18	intron variant	7
NLRP3	1	rs7525979	T	C	0.15	synonymous codon	5
NLRP3	1	rs79796552	G	A	0.14	intron variant	6
NLRP3	1	rs4925648	T	C	0.13	intron variant, upstream variant 2 KB	7
NLRP3	1	rs10925022	G	A	0.12	intron variant	5
NLRP3	1	rs36021952	A	G	0.11	intron variant	3a
NLRP3	1	rs72771992	G	T	0.11	utr variant 5 prime	7
NLRP3	1	rs74154644	T	C	0.11	intron variant	5
NLRP3	1	rs45624634	A	C	0.11	intron variant	4
NLRP3	1	rs4925651	T	G	0.10	intron variant	5
NLRP3	1	rs4925543	A	G	0.10	synonymous codon	5
NLRP3	1	rs7524914	C	T	0.09	intron variant	6
NLRP3	1	rs73136263	T	G	0.03	utr variant 5 prime	7
NLRP3	1	rs55914518	A	G	0.02	intron variant	6
NLRP3	1	rs35433972	T	C	0.02	intron variant	5
NLRP3	1	rs116096527	A	G	0.01	intron variant	5
CASP1	11	rs79180143	A	C	0.28	intron variant, utr variant 3 prime	7
CASP1	11	rs531542	A	G	0.14	intron variant	3a
CASP1	11	rs580253	A	G	0.14	intron variant, synonymous codon	7
CASP1	11	rs7925706	T	C	0.13	intron variant, utr variant 5 prime	4
CASP1	11	rs556205	G	T	0.08	intron variant	6
CASP1	11	rs75775137	G	A	0.06	intron variant	5

CHR, chromosome; SNP, single nucleotide polymorphism; A1, minor allele; A2, ancestral allele; MAF, minor allele frequency; utr, untranslated region.